Electrospinning of commercially available medical silicone rubber

Polyelectrolyte multilayer (PEM) films, established using the layer-by-layer (LbL) technique, are attractive for controlled drug delivery in order to improve tissue regeneration. For instance, the LbL-deposition provides the possibility to incorporate biomolecules via electrostatic interactions for drug delivery, which might be moreover combined with a stable biofunctionalization via covalent binding of biomolecules such as cell adhesion motifs to the outer layer. Here, the influence of covalent biofunctionalization of PEM deposited on poly(L-lactide) (PLLA) on the release profiles of avidin fluorescein isothiocyanate (avidin-FITC) incorporated as model drug within the PEM is demonstrated.